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人参糖肽对糖基化抑制作用的体外研究 被引量：5

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摘要 目的研究人参糖肽对体外糖基化的抑制作用。方法分别应用血红蛋白-δ-葡萄糖酸内酯实验、牛血清白蛋白-葡萄糖实验和N-乙酰-甘氨酰-赖氨酸甲基酯-核糖实验,体外观察人参糖肽注射液(2、4、8、16和32mg/ml)对糖基化产物形成的抑制效果。结果血红蛋白-δ-葡萄糖酸内酯实验显示,人参糖肽以浓度依赖方式抑制早期糖基化产物糖化血红蛋白A1c(HbA1c)的产生。牛血清白蛋白-葡萄糖实验和N-乙酰-甘氨酰-赖氨酸甲基酯-核糖实验表明,人参糖肽以浓度依赖方式明显抑制晚期糖基化终产物的形成。结论人参糖肽对体外糖基化有明显抑制作用。
作者 张旗 王诗雯 苗春生 李才
机构地区 吉林大学药学院实验药理与毒理学教研室
出处 《中国老年学杂志》 CAS CSCD 北大核心 2009年第5期557-559,共3页 Chinese Journal of Gerontology
关键词 人参糖肽 糖基化 晚期糖基化终产物 抑制作用
分类号 R966 [医药卫生—药理学]
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参考文献8

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二级参考文献29

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中国老年学杂志
2009年 第5期

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