内蒙古地区弥漫性大B细胞淋巴瘤50例临床病理分析

Diffuse large B cell lymphoma in Inner Mongolia area:a clinicopathological analysis of 50 cases

目的探讨弥漫性大B细胞淋巴瘤（DLBCL）的免疫表型特点。方法收集不同部位的DLBCL50例，通过免疫组化方法检测DLBCL的免疫表型并进行分类。结果50例CD20和CD79a均（＋），13例CD45RO（＋），5例CD43（＋），17例CD10（＋），25例bcl-6（＋），28例MUM-1（＋）。根据免疫表型分类，21例为生发中心B细胞样DLBCL，29例为活化B细胞样DLBCL。结论内蒙古地区DLBCL的发病部位涉及多个器官和组织，其中以颈部、扁桃体和胃肠道为多见。该地区DLBCL病例B细胞标记物CD20和CD79a均（＋），部分病例T细胞标记物CD45RO（＋），这可能是内蒙古地区DLBCL病例的特点。

Purpose To investigate the immunophenotypic feature of diffuse large B cell lymphoma （DLBCL）. Methods 50 cases of DLBCL were detemfined with immunohistochemical staining, and distinguished from other cases according to their immunophenotypic features. A penal of antibodies CD20, CD3, CD79a, CIM3, CD45RO, CD10, bcl-6 and MUM-1 were used in this study. Results All of the cases expressed CD20 and CD79a; CD45RO, CD43, CD10, bcl-6 and MUM-1 were expressed in 13 cases, 5 cases, 17 cases, 25 cases and 28 cases, respectively; According to the immunophentypes, 21 cases were classified as germinal center B-cell-like DLBCL, and the other 29 cases as activated B-cell-like DLBCL. Conclusions The DLBCL in Inner Mongolia are localized in multiple organs or tissues, most commonly in the neck, tonsil and gastrointestinal tract, which express the markers of B cells CD20 and CD79a in all cases, and CD45RO, a T cell marker, in some cases. Maybe it is the feature of DLBCL cases in the Inner Mongolia.