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人巨细胞病毒感染对腮腺导管上皮细胞角蛋白K8和K18表达的影响 被引量：4

Effect of HCMV on expressions of K8 and K18 in duct epithelial cells of salivary gland
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摘要 目的研究人巨细胞病毒（HCMV）感染对腮腺导管上皮细胞角蛋白K8和K18表达的影响。方法用免疫组化方法研究腮腺巨细胞包涵体病（PCID）石蜡包埋组织中巨细胞病毒立即早期抗原和角蛋白K8、K18的表达。结果PCID腮腺组织导管上皮出现包涵体巨细胞；包涵体巨细胞HCMV抗原DDG9／CCH2阳性；包涵体巨细胞角蛋白K8表达呈阴性，而K18表达呈强阳性。结论HCMV感染腮腺导管上皮细胞诱发角蛋白K8降解，K18表达上调是一种反应性改变；单层上皮角蛋白网具有维持上皮细胞机械力学完整性的功能。 Objective To study the effect of human cytomegalovirus （HCMV） on expressions of K8 and K18 in duct epithelial cells of salivary gland. Methods The expressions of immediate early antigen of HCMV, K8 and K18 were detected by immunohistochemistry staining in tissues embedded in paraffin of parotid cytomegalic inclusion disease（PCID）. Results Cytomegly bearing inclusion appeared in duct epi- thelium of PCID. DDG9/CCH2 antigen of HCMV was expressed in cytomegly bearing inclusion. K8 was negative in these cytomegly while K18 was intensively positive. Conclusion It is suggested that breaking down of K8 be induced in parotid duct epithelial cells infected by HCMV and that up-regulation of K18 may be a reactive change. Keratin network in simple epithelium functions to impart mechanical integrity to cells.
作者 杨国嵘 黄高昇 薛永杰 贾兴民 何晓霞 郁荣 贺雪娇
机构地区 解放军第一医院病理科 第四军医大学病理教研室 兰州大学临床医学院
出处 《中华微生物学和免疫学杂志》 CAS CSCD 北大核心 2009年第2期117-120,共4页 Chinese Journal of Microbiology and Immunology
关键词 人巨细胞病毒 腮腺导管上皮细胞 角蛋白8 角蛋白18 Human cytomegalovirus Parotid duct epithelial cell Keratin 8 Keratin 18
分类号 R51 [医药卫生—内科学]
  • 相关文献

参考文献15

  • 1吴奇光 见:武忠弼 杨光华 主编.口腔及颌面部疾病[A].见:武忠弼，杨光华，主编.中华外科病理学[C].北京:人民卫生出版社,2002.515.
  • 2杨国嵘,黄高昇,王恩华,宋继谒,郭英,王娟红,梁蓉,王哲,闫庆国,冯骥良.感染HCMV的腮腺导管上皮细胞CK和EMA丢失[J].临床与实验病理学杂志,2003,19(5):465-467. 被引量：9
  • 3Gluschankof P, Suzan M. HIV-1 gag polyprotein rescues HLA-DR intracellular transport in a human CD4^+ cell line. Virology,2002, 300( 1 ) : 160-169.
  • 4Conaldi PG, Bottelli A, Baj A, et al. Human immunodeficiency virus-1 tat induces hyperproliferation and dysregulation of renal glomerular epithelial cells. Am J Pathol, 2002, 161 ( 1 ) : 53-61.
  • 5Ohshima K, Suzumiya J, Kanda M, et al. Genotypic and phenotypic alterations in Epstein-Barr virus-associated lymphoma. Histopathology, 1999, 35(6): 539-550.
  • 6吕庆杰,闻德亮,李冠群,王伟.小儿巨细胞包涵体病组织中病毒抗原检测及其临床意义的研究[J].中华儿科杂志,1999,37(8):481-483. 被引量：9
  • 7Zhang Y, Schneider RJ. Adenovirus inhibition of cell translation facilitates release of virus particles and enhances degradation of the cytokeratin network. J Virol, 1994, 68(4) : 2544-2555.
  • 8Fuehs E, Cleveland DW. A structural scaffolding of intermediate filaments in health and disease. Science, 1998, 279 ( 5350 ) : 514-519.
  • 9Hutton E, Paladini RD, Yu QC, et al. Functional differences between keratins of stratified and simple epithelia. J Cell Biol, 1998, 143(2) : 487-499.
  • 10Smith GA, Enquist LW. Break ins and break outs: viral interactions with the cytoskeleton of mammalian cells. Annu Rev Cell Dev Biol, 2002, 18: 135-161.

二级参考文献3

  • 1金奇.巨细胞病毒[A].见:金奇主编.医学分子病毒学[C].北京:科学出版社,2001.762～86.
  • 2吴奇光 见:武忠弼 杨光华 主编.口腔及颌面部疾病[A].见:武忠弼，杨光华，主编.中华外科病理学[C].北京:人民卫生出版社,2002.515.
  • 3王世俊，中国实用儿科杂志，1994年，9卷，346页

共引文献17

同被引文献30

  • 1杨国嵘,黄高升,王娟红,王恩华,王哲,宋继谒.人巨细胞病毒对涎腺导管上皮细胞增殖的影响[J].中华口腔医学杂志,2004,39(4):298-301. 被引量：2
  • 2金奇.巨细胞病毒[A].见:金奇主编.医学分子病毒学[C].北京:科学出版社,2001.762～86.
  • 3吴奇光 见:武忠弼 杨光华 主编.口腔及颌面部疾病[A].见:武忠弼，杨光华，主编.中华外科病理学[C].北京:人民卫生出版社,2002.515.
  • 4LANDOLFO S,GARIGLIO M,GRIBAUDO G,et al.The human cytomegalovirus[J].Pharmacol Ther,2003,98(3):269-297.
  • 5WANG X, HUONG S M, CHIU M L, et al. Epidermal growth factor receptor is a cellular receptor for human cytomegalovirus[J]. Nature, 2003, 424(6947): 456-461.
  • 6GLUSCHANKOF P,SUZAN M.HIV-1 gag polyprotein rescues HLA-DR intracellular transport in a human CD4^+cell line[J].Virology,2002,300(1):160-169.
  • 7CONALDI P G,BOTTELLI A,BAJ A,et al.Human immunodeficiency virus-1 tat induces hyperprolifer-ation and dysregulation of renal glomerular epithe-lial cells[J].Am J Pathol,2002,161(1):53-61.
  • 8ALLART S,MARTIN H,DETRAVES C,et al.Human cytomegalovirus induces drug resistance and alter-ation of programmed cell death by accumulation of deltaN-p73alpha[J].J Biol Chem,2002,277(32):29 063-29 068.
  • 9SMITH G A,ENQUIST L W.Break ins and break outs:viral interactions with the cytoskeleton of Mammalian cells[J].Annu Rev Cell Dev Biol,2002,18:135-161.
  • 10Knipe D and Howley P.Fields Virology[M].Philadelphia:Lippincott,Williams and Wilkins,2001.2629-2673.

引证文献4

二级引证文献1

中华微生物学和免疫学杂志
2009年 第2期

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