百草枯中毒的药物治疗研究进展

Progress of research on drug treatment of paraquat intoxication

农药百草枯属剧毒除草剂,重度中毒患者可在短时间内死于多脏器功能衰竭;中度中毒时主要损害肺脏,患者发生急性呼吸窘迫综合征,后期多死于肺纤维化。因尚无特效解毒药,临床救治多以对症和支持治疗为主,病死率极高。寻求有效的治疗药物已成为百草枯中毒的研究热点。本文对临床救治中常用的及近年来新发现的对百草枯中毒有治疗作用的药物作一综述。

Pesticide paraqudt is a rank toxic herbicide, the severely intoxicated patient soon die of multiple organ failure. The main damage organ of the midrange intoxicated patient is the lung. Acute respiratory distress syndrome proceeds pulmonary fibrosis. Because no specific antidote has been found, symptomatic and supportive treatments are mainly used in clinical salvage. The search for effective management drug consequently becomes the hot spot of the investigation. Research on drug treatment of acute paraquat intoxication is reviewed in this article.