多靶点药物治疗及药物发现

Multi-target therapeutics and new drug discovery

作用于单靶点的药物在治疗复杂性疾病如肿瘤、糖尿病、感染性疾病时常常疗效不佳或毒性较大。多靶点药物可以同时调节疾病网络系统中的多个环节,不易产生抗药性,对各靶点的作用产生协同效应,达到最佳的治疗效果。本文对多靶点药物治疗的特点、分类情况、发现策略、筛选模型及已在临床使用的多靶点治疗药物进行综述,并探讨中药在多靶点药物治疗应用中的潜力。

Drugs acting on individual molecular targets usually exert unsatisfying therapeutic effects or have severe toxicity when used in diseases of complicated causes such as tumor, diabetes and inflammation. Multi-target therapeutics which regulates multiple nodes of the disease network simultaneously shows synergistic effect, is unlikely to induce resistance and provides optimal clinical use. This review summarized the characteristics, classification, development strategies and screening models, current multi-target therapeutic drugs used in clinic and also explored the potential of TCM in multi-target therapeutics.