苯溴马隆结合威草胶囊治疗痛风的临床疗效

Clinic Effect of Benzbromarone Combined with Weicao Capsule in the Treatment of Gout

目的:研究中西医结合对痛风的治疗作用。方法:将160例痛风患者分为2组。治疗组:中西医结合,苯溴马隆片50mg/d,威草胶囊2粒/次,3次/d;对照组:苯溴马隆片50mg/d,1次。结果:①治疗组与对照组总有效率分别为95%、70%,两组有统计学意义(P<0.05)。②治疗组血β2-M明显下降(P<0.01),对照组无变化(P>0.05),治疗组血红蛋白较治疗前明显改善(P<0.01),两组有明显统计学意义(P<0.01),24h尿蛋白治疗组治疗后有显著改善(P<0.01),对照组无统计学意义(P>0.05),两组均能改善pH值(P<0.01)。组间比较无统计学意义(P>0.05)。③两组均能降低血尿酸,但治疗组更为明显(P<0.01)。④对BUN、Scr、Ccr,血脂治疗组治疗前后有显著改善(P<0.01),对照组无变化(P>0.05),两组比较有明显统计学意义。结论:中西医结合能显著降低血尿酸及血脂,改善肾功能,减少蛋白尿。

Objective： To study therapeutic effect of benzbromarone combined with Weicao capsule on gout. Methods： A total of 160 gout patients were divided into control group （n=80, treated with benzbromarone） and treatment group （n=80, treated with benzbromarone combined with a traditional Chinese medicine, Weicao capsule）. Results： Total effective rate of control group was 70% ,while that of treatment group was 95%（P〈0.05）. Blood β2 microglobulin （β2M） in treat ment group was significantly decreased （P〈0.01）, while that in control group changed little （P 〉0.05）. Blood hemoglobin in treatment group was ameliorated better than that of patients in control group（P〈0.01）. The 24 h qualitative test for urinary nitrogen of patients in treatment group was significantly decreased （P〈0. 01）, while that in control group changed little （P〉 0. 05）. pH value of patients in both groups was ameliorated, and no difference was found between both groups （P〉0. 05）. Blood uric acid level in both groups reduced significantly, but that in treatment group changed much more than that in control group （P〈0.01）. Blood urea nitrogen （BUN）, serum creatinine （Scr） and creatinine clearance （Ccr） in treatment group were signifi cantly ameliorated （ P 〈 0. 01 ）, but these indices in control group changed little （ P 〉 0. 05 ）. Conclusion： Benzbromarone combined with Weicao capsule can reduce blood uric acid, blood lipidand urinary protein and improve renal function.