摘要
通过报道1例典型的月经前哮喘(PMA),结合复习相关文献,讨论PMA的患病率、发病机制和治疗。40%左右女性哮喘患者月经前出现哮喘加重,但经平喘治疗后仍每次月经前均发作或加重的典型PMA仍少见,PMA的发病机制尚不清楚,可能与体内性激素改变有关,其治疗除哮喘防治指南中常用药物外还包括白三烯调节剂、黄体酮肌肉注射、口服避孕药、促性腺激素释放激素类似物等甚至包括双侧卵巢切除等,国外多种特殊治疗疗效不一,缺乏大量临床实验,所以有待更多相关研究。
A case of premenstrual asthma （PMA） was reported in this paper, and the related literatures were reviewed to discuss the prevalence, mechanism and treatment of PMA. About 40% women with asthma were reported premenstrual deterioration in their symptoms, but the classic case of PMA relapsing after anti-asthmatic treatments or aggravating was rarely reported. The mechanism of PMA remains unclear, and it may have a relationship with the change of intrinsic sex hormone. So its therapy includes those drugs listed in the Asthma Prevention Guideline as well as leucotriene regulator, intramuscular progesterone, oral contraceptives, gonadotropin releasing hormone analogues, or even the operation of bilateral oophorectomy. The specific treatments used in some other countries show different efficiencies and lack of enough supports of clinical trials.
出处
《武汉大学学报（医学版）》
CAS
北大核心
2009年第2期266-268,共3页
Medical Journal of Wuhan University
关键词
月经前哮喘
月经
哮喘
Premenstrual Asthma
Menstruation
Asthma
