结直肠癌肝转移的分子机制研究进展

Advanced Research on Molecular Mechanisms of Hepatic Metastasis in Colorectal Cancer

结直肠癌肝转移涉及许多分子机制,参与结直肠癌肝转移的有二十多个分子因子,这些分子因子基于其功能分成4个部分:蛋白质水解、黏附、血管生成和细胞生存。通过理解其中许多复杂的分子机制,有望发现一些新的检测和治疗靶点,以期达到预防转移和提高病人生存率的目的。

This review has identified many recent advances involved in colorectal cancer hepatic metastasis. Twenty molecular factors were identified and included in this review. The molecular factors were separated into four groups based on their functions as proteolysis, adhesion, angiogenesis and cell survival. In order to better understanding the complex molecular events involved in metastasis, novel screening and therapeutic tools may be developed for the ultimate goal of preventing metastasis and increasing survival rate of colorectal cancer.