中国成人标准肝体积评估公式的临床研究

Estimation Formula of Standard Liver Volume for Chinese Adults

目的探讨适合中国成人的标准肝体积(SLV)评估公式。方法回顾性分析我院115例成人间活体不包括肝中静脉的右半肝移植供体的临床资料。术中测量移植肝体积和质量,根据CT测定移植肝占全肝体积的比例计算出实际全肝体积。进行简单直线回归分析和多重线性回归分析,建立回归方程并与其他SLV评估公式比较。结果所有供体均为中国成人,年龄(35.97±9.6)岁,男∶女=60∶55。术前CT测得的移植肝体积为(727.47±136.17)mL,占全肝的55.59%±6.70%。术中测得的移植肝体积为(581.73±96.14)mL,实际全肝体积为(1053.08±167.56)mL。通过回归分析,建立回归方程:SLV=11.508×BW+334.024。除香港公式低估了本组供体的肝脏体积,其余公式均高估了本组研究对象的肝脏体积。结论适合中国成人的SLV公式为:SLV=11.508×BW+334.024。

Objective To develop a formula estimating standard liver volume （SLV） for Chinese adults. Methods We retrospectively reviewed 115 cases of living donors for right lobes of liver transplants, not including the middle hepatic veins, in our hospital. The weights and volumes of the right lobe liver grafts were measured and recorded in the surgery. The actual total volume of liver was calculated from the right lobe graft volume divided by the proportion of the right lobe as indicated in the computed tomography. Simple linear regression analysis and stepwise multiple linear regression analysis were undertaken to develop a formula for calculating the total liver volume, which was compared with other existing formulae. Results The liver donors had a mean age of （35.97± 9.6） years old, and a female to male ratio of 60 ： 55. The computed tomography detected a mean volume of （727.47±136.17） mL of right lobe, which occupied 55.59%±6. 70% of the entire livers. The right lobe grafts had an actual volume of （581.73±96. 137） mL and the donors had an actual total liver volume of （1053.08±167.56） mL. A formula was developed for calculating the standard liver volume： SLV（mL）= 11. 508 × Body Weight＋ 334. 024. The HongKong formula underestimated, whereas all of the other formulae overestimated the actual liver volume of the donors. Conclusion The standard liver volume of Chinese adults can be calculated as： SLV = 11. 508 × Body Weight＋334. 024.