期刊文献+

颅内静脉窦血栓形成的早期诊断和治疗方法探讨 被引量:8

下载PDF
导出
摘要 目的探讨颅内静脉窦血栓形成(CVST)的早期诊断和治疗方法,分析D-二聚体检测对早期诊断CVST的意义。方法回顾性分析42例CVST患者的病因、临床表现、影像学特征、治疗方法及其中19例患者的D-二聚体检测结果。结果42例患者平均年龄(36±18)岁,男女比例为0.75∶1。头痛、呕吐为早期最常见的临床表现,感染和恶性肿瘤是最常见的病因,磁共振血管造影(MRA/MRV)和数字减影脑血管造影(DSA)表现为一处或多处静脉窦闭塞或不完全闭塞。19例有头痛和其他神经症状的患者用乳胶凝集试验检测血浆D-二聚体,其中15例>500 ng/mL(检测时间在起病30 d以内),4例呈阴性(检测时间1例在起病30 d以内检查,3例在起病30 d后)。经脱水降颅压、低分子肝素抗凝、尿激酶局部溶栓和血管内介入治疗后,42例患者中28例(66.7%)基本痊愈,7例(16.7%)症状好转,6例(14.3%)无变化,1例(2.4%)死亡。其中5例采用血管内治疗为主的重症患者4例痊愈,1例死亡。结论CVST临床表现复杂多样,D-二聚体检测可能具有良好的阴性预测作用,特别是对发病30 d以内的患者。MRI/MRA及DSA检查是目前诊断的金标准。抗凝治疗具有良好的治疗效果,血管介入治疗对改善重症CVST患者预后有重要意义。
出处 《四川大学学报(医学版)》 CAS CSCD 北大核心 2009年第2期353-355,共3页 Journal of Sichuan University(Medical Sciences)
  • 相关文献

参考文献14

  • 1Crassard I, Bousser MG. Cerebral venous thrombosis. J Neuroophthalmol, 2004, 24 (2) : 156-163.
  • 2Tardy B, Tardy-Poneet B, Viallon A, et al. D-dimer levels in patients with suspected acute cerebral venous thrombosis. Am J Med,2002,113(3) :238-241.
  • 3Lalive PH, de Moerloose P, Lovblad K, et al. Is measurement of D-dimer useful in the diagnosis of cerebral venous thrombosis? Neurology, 2003 , 61 (8) : 1057-1060.
  • 4Kosinski CM, Mull M, Schwarz M, et al. Do normal D-dimer levels reliably exclude cerebral sinus thrombosis? Stroke, 2004, 35(12) :2820-2825.
  • 5Crassard I, Soria C, Tzourio C, et al. A negative D-dimer assay does not rule out cerebral venous thrombosis: a series of seventy-three patients. Stroke,2005 ,36(8) :1716-1719.
  • 6Stein PD, Hull RD, Patel KC, et al. D-dimer for the exclusion of acute venous thrombosis and pulmonary embolism, a systematic review. Ann Intern Med, 2004,140(8) : 589-602.
  • 7Chaudhary MY, Ahmed I, Afzal B, et al. Dural sinus thrombosis, frequency and imaging diagnosis. J Coll Physicians Surg Pak,2006,16(6) :400-403.
  • 8Brucker AB, Vollert-Rogenhofer H, WagnerM, et al. Heparin treatment in acute cerebral sinus venous thrombosis: a retrospective clinical and MR analysis of 42 cases. Cerebrovasc Dis, 1998 , 8(6): 331-337.
  • 9Sacco RL, Adams R, Albers G,etal. Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack. Stroke,2006,37(2) :577-617.
  • 10Einhaupl K, Bousser MG, de Bruijn SF, et al. EFNS guideline on the treatment of cerebral venous and sinus thrombosis. Eur J Neurol,2006,13(6):553-559.

二级参考文献25

  • 1李林,王伟民,赵刚,贺道华,王伟中.血管内局部溶栓治疗颅内静脉窦血栓[J].中国微侵袭神经外科杂志,2005,10(1):16-19. 被引量:12
  • 2Manzione J, Newman GC, Shapiro A, et al. Diffusion- and perfusion- weighted MR imaging of dural sinus thrombosis. AJNR,2000,21:68-73.
  • 3Bousser MG. Cerebral venous thrombosis: nothing, heparin, or local thrombolysis? Stroke, 1999,30:481-483.
  • 4de Bruijn SF, Stam J. Randomized, placebo-controlled trial of anticoagulant treatment with low-molecular-wight heparin for cerebral sinus thrombsis. Stroke. 1999.30:484-488.
  • 5Einhaupl KM, Villringer A, Meister W, et al. Heparin treatment in sinus venous thrombosis. Lacet,1991,338:597-600.
  • 6Scou JA, Pascuzzi RM, Hall PV, et al. Treatment of dural sinus thrombosis with local urokinase infuion: case report. J Neurosurg,1988,68:284-287.
  • 7D'Alise MD, Fichtel F, Horowitz M. Sagittal sinus thrombosis following minor head injury treated with continuous urokinase infusion. Surg Neurol, 1998,49:430-435.
  • 8Chow K, Gobin YP, Saver J, et al. Endovascular treatment of dural sinus thrombosis with rheolytic thrombectomy and intra-arterial thrombolvsis. Stroke, 2000,32:1420-1425.
  • 9Gurley MB, King TS, Tsai FY. Sigmoid sinus thrombosis associated with internal jugular venous occlusion : direct thrombolystic treatment.J Endovasc Surg, 1996,3:306-314.
  • 10Frey JL, Muro GJ, McDougall CG, et al. Cerebral venous thrombosis: combined intrathrombus rtPA and intravenous heparin.Stroke, 1999,30:489-494.

共引文献86

同被引文献50

  • 1吉训明,凌锋,贾建平,李慎茂,缪中荣,朱凤水,宿英英,闵保权,王向波,张鸿祺,张鹏,支兴龙,宋庆斌,秦晓红,刘香美,张虹.多途径联合血管内治疗颅内静脉窦血栓形成[J].中华放射学杂志,2005,39(1):87-91. 被引量:75
  • 2王玉芝,孙淑嫔,张玉香.产褥期颅内静脉窦血栓形成的护理[J].吉林医学,2005,26(11):1147-1148. 被引量:9
  • 3冯东福,卢亦成,楼美清,朱志安.脑静脉系统血流变化对颅内压调节的影响[J].中国临床神经外科杂志,2006,11(7):440-442. 被引量:7
  • 4贾建平.神经病学[M].北京:人民卫生出版社,2008,420
  • 5吴江.神经病学[M].北京:人民卫生出版社,2009:165.
  • 6Bousser MG,Ferro JM.Cerebral venous thrombosis:an up-date[J].Lancet Neurol,2007,6(2):162.
  • 7Crassard I,Bousser MG.Cerebral venous thrombosis[J].Neuroophthalmol,2004,24(2):156.
  • 8吴江,贾建平,崔丽英.神经病学[M].2版.北京:人民卫生出版社,2011:179.
  • 9Bousser MG, Ferro JM. Cerebral venous thrombosis: an update. Lancet Neurol, 2007,6(2) : 162-170.
  • 10Imtiaz KE, Rajpara S, Majeed T. Cerebral venous sinus thrombosis: a diagnosis not to be missed. Br J Hosp Med (Lond), 2010, 71 (9) :528-529.

引证文献8

二级引证文献16

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部