广东省人群乙型肝炎病毒感染模式分析

Analysis of hepatitis B virus infection models in population in Guangdong Province

目的：了解广东省人群各种乙肝病毒感染模式的发生情况及其与年龄、性别和城乡的关系。方法：采取多阶段随机抽样的方法，抽取广东省的6个县区3925人为研究对象，进行问卷调查和乙肝病毒血清学指标检测。结果：广东省人群乙肝病毒感染模式共有11种，常见模式6种，发生率从高到低依次为：模式“2”（40．36％）、五项全阴模式（22．73％）、“25”（22．29％）、“145”（6．65％）、“135”（4．23％）和“5”（3．52％）。随着年龄增大，模式“145”、“5”、“25”发生率升高，模式“2”的发生率下降，差异有显著性；5—14岁人群五项全阴模式的发生率最高。男性模式…2’的发生率显著高于女性，但模式“25”的发生率显著低于女性。城市人群模式“145”、“135”和“5”的发生率均显著低于农村人群，但模式“2”和五项全阴模式的发生率显著高于农村人群。结论：广东省人群乙肝病毒感染模式与同时期其他地区相比，单独HBsAb阳性等恢复期模式发生率较高，“大三阳”和“小三阳”等感染期模式发生率较低，说明广东省的预防接种工作开展良好，人群免疫水平较高。

Objectives：To investigate incidences of hepatitis B virus infection models for Guangdong people and analyze the relation of the models to people＇s age, sex and source. Methods： Through multistagerandom sampling methods, we selected 3925 people from six districts. All the objects were investigated by the questionnaire and examined the serological market by blood sam- piing. Results：There were 11 infection models for Guangdong people and 6 of them are frequent models. The positive rates of model＂2＂, ＂all five markets negative＂, ＂25＂, ＂145＂, ＂135＂ and ＂5＂are 40. 36% ,22. 73% ,22. 29% ,6. 65% ,4. 23% and 3. 52% respectively. With age increasing, the positive rates of model＂145＂, ＂5＂ and ＂＇25＂ increase and the positive rate of model ＂2＂ decrease. Children aged 5 - 14 have the highest positive rates of＂ all five markets negative＂. To men, The positive rate of model ＂2＂ is higher than women but the rate of model ＂25＂ is lower than women significantly. To citizen people, the positive rates of model ＂145＂,＂ 135＂ and ＂5＂ are lower than those of countryside people but the rates of model ＂2＂ and ＂all five markets negative＂ are higher than those of countryside people significantly. Conclusion： Comparing with other districts, The rates of recovery period models especially single - HBsAb - positive model are high and the rates of infective period models such as ＂145＂ and ＂135＂ are low in Guangdong Province. It indicates that our immunization strategy is effective and the protective level of people is high in Guangdong Province.