摘要
合成了一种新的含有5-氟尿嘧啶的Keggin型磷钨多金属氧酸盐C4H4FN2O2H2PW12O40.8 H2O,通过元素分析、IR、UV、XRD1、83W NMR和TG对其结构进行了表征.IR、UV和XRD图谱表明,该化合物具有Keggin与5-氟尿嘧啶环结构.183W NMR表明,该化合物中的钨原子处于相同的化学环境中.TG表征结果表明,该化合物具有较好的热稳定性,其热失重分2步完成.在人肾胚胎细胞系HEK293细胞内,以5-氟尿嘧啶为阳性对照药物,用MTT法对所合成的化合物进行了体外细胞毒性研究,该化合物的TC50为1.48×10?5mol.L?1,其毒性低于5-氟尿嘧啶.
A novel polyoxometalate containing 5-fluorouracil with Keggin structure C4H4FN2O2H2PW12O40 · 8H2O was synthesized and structurally characterized by elemental analysis, IR spectra, UV spectra, X-ray powder diffraction, ^183W NMR and TG. The results of IR, UV and XRD indicted that the compound has Keggin and ring structures of 5-fluorouracil. It is shown that tungsten atoms of the compound are in the same chemical environment by the ^183W NMR spectra of the compound. The result of TG showed that the compound has good thermal stability, and the weightlessness has two steps. In human renal embryonic cell HEK293 with 5-fluorouracil for the positive control group, the ivtro cytotoxicity test of the compound was studied by MTT method. The TC50 of the compound is 1.48×10^-5 mol · L^-1 and its toxicity is lower than 5-fluorouracil.
出处
《北京理工大学学报》
EI
CAS
CSCD
北大核心
2009年第2期160-163,共4页
Transactions of Beijing Institute of Technology
基金
中国工程物理研究院化工材料研究所资助项目(62601070215)
