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整合子在产ESBLs志贺菌中的检测

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摘要 目的:探讨产超广谱β-内酰胺酶(ESBLs)志贺菌多重耐药与整合子的关系,研究其耐药机制。方法:圆盘扩散方法检测抗菌药物敏感性,改良三维试验对可疑产ESBLs志贺菌进行检测,多重PCR检测、、类整合子,并对整合子进行DNA测序以确定携带的耐药基因盒。结果:在10株产ESBLs志贺菌中全部检出类整合子,其可变区含有dfrA17-aadA5基因盒。结论:本地区产ESBLs志贺菌全部含有类整合子,分别编码磺胺类和氨基糖苷类多重耐药性。
作者 边锋芝 孙玉国 苑广盈 李金文 宋秉跃 郑秀峰 张延芳
机构地区 济南市第四人民医院检验科
出处 《陕西医学杂志》 CAS 2009年第3期357-359,共3页 Shaanxi Medical Journal
关键词 志贺菌属/免疫学 @整合子 β内酰胺酶类/化学 微生物敏感性试验
分类号 R378.21 [医药卫生—病原生物学] R378.1 [医药卫生—病原生物学]
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参考文献8

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陕西医学杂志
2009年 第3期

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