抗组胺新药非索非那定的合成进展

Development of Synthesis of a New Antihistamine Drug Fexofenadine

非索非那定是第二代抗组胺药物,用于治疗过敏性疾病,无嗜睡,无心脏毒性,副作用小。综述了其合成的主要方法,比较了各自的优缺点。

Fexofenadine was the second era antihistamine drug used to treat anaphylaxis, and was not sedative and heart toxicity. It had small poison and secondary reaction. In this paper, the main synthetic methods of fexofenadine weve reviewed, and both virtue and shortcoming were compared.