1-苄基-4-(4-甲氧基)-苯基-1,2,3-三唑的合成

Preparation of 1-Benzyl-4-(4-Methyloxy)Phenyl-1, 2, 3-Triazole

采用氯苄和叠氮化钠在乙醇中反应制备了苄叠氮,进而与对甲氧基苯乙炔进行1,3-偶极环加成反应合成了未见报道的1-苄基-4-(4-甲氧基)-苯基-1,2,3-三唑,产率达到了48%,产物结构经NMR和MS确认。

Benzyl azide was synthesized in ethyl alcohol by substitution reaction with benzyl chloride and sodium azide, and then 1-benzyl-4-（4-methyloxy）phenyl-1, 2, 3-triazole was prepared by 1,3-dipolar cycloaddition of benzyl azide and 4-methoxyphenylacetylene, with the yield of 48 %. The structures of the products were characterized by NMR and MS.