九华痔疮栓治疗肛裂致过敏性休克

Anaphylactic shock occurring after administration with Jiuhuazhichuang suppositories for anal fissure

1例17岁女性,因肛裂使用九华痔疮拴治疗。在首次用药后2～3min,患者突然出现全身瘙痒、嘴唇肿胀,皮肤出现大小不等的风团。立即就诊,给予地塞米松10mg肌内注射,50%的葡萄糖注射液20ml+10%葡萄糖酸钙10ml静脉推注,并给予开塞露20ml将痔疮栓排出。之后患者出现全身无力,意识模糊。查体:P108次/min,R30次/min,BP70/48mmHg。立即肌内注射0.1%肾上腺素0.3ml和静脉补液。4h后症状完全消失,P70次/min,R18次/min,BP120/80mmHg。患者痊愈出院。

A 17-year-old girl received a Jiuhuazhichuang suppository for her anal fissure. About 2-3 minutes after starting administration with the suppository, the girl abruptly developed pruritus, lip swelling, and wheal of various sizes on her skin. After hospitalization, she was treated with IM dexamethasone 10 mg, Ⅳ 10% calcium gluconate 10 ml diluted in 50% glucose 20 ml. Her Jiuhuazhichuang suppository was eliminated with rectal administration of a Kaisailu （20 ml of a glycerin solution ）. Later, she experienced generalized asthenia and unconsciousness, her pulse rate was 108 beats/min, her respiratory rate was 30 breaths/min, and her BP was 70/48 mm Hg. IM 0. 1% adrenaline 0.3 ml and Ⅳ fluids were given immediately. Four hours later, the symptoms completely disappeared. An examination showed a pulse rate of 70 beats/rain, a respiratory rate of 18 breaths/min, and a BP of 120/80 mm Hg.