早期帕金森病扩散张量成像的初步研究

Diffusion Tensor Imaging in Early-stage Parkinson' Disease:A Preliminary Study

目的评价MRI扩散张量成像(DTI)技术在早期帕金森病(PD)中的诊断价值。资料与方法对30名早期PD患者和30例匹配的健康老年对照组的黑质-纹状体区进行了常规MR平扫和DTI扫描,对双侧黑质-纹状体纤维环路穿越的部位:黑质致密部、底丘脑核、苍白球、壳核、尾状核连续层面的FA值和DCavg值进行测量和统计分析。结果PD组黑质致密部、黑质致密部与底丘脑核之间部位的FA值显著低于对照组(P值<0.05)。苍白球、壳核、尾状核等部位的FA值和DCavg值与对照组相比无显著差异。结论DTI能无创性定量测量早期PD黑质-纹状体区病变的FA值和DCavg值,是对早期PD黑质-纹状体区进行定量评估的一种敏感的研究手段。

Objective To evaluate the diagnostic value of MR Diffusion tensor imaging in early-stage Parkinson＇ s Disease （PD）. Materials and Methods Diffusion tensor imaging as well as conventional MRI was performed in thirty early stage PD patients and 30 age-matched normal controls to measure the fractional anisotropy （FA） and average diffusion coefficient（DCavg） values in the region of interest along caudate,putamen, globus pallidus, subthalamic nucleus and substantia nigra pars compacta,in which most of the nigrostriatal dopaminergic neurons are passed through. Results In contrast to healthy controls, PD patients had lower FA values from the pars compacta of substantia nigra to subthalamic nucleus, but there were no difference in FA and DCavg values between PD patients and controls in caudate, putamen and globus pallidus. Conclusion DTI is a noninvasive technique that provid a sensitive indicator for FA and DCavg values abnormality in nigrostriatal structures, which may contribute to the early diagnosis of Parkinson＇ s Disease.