结肠癌转移相关细胞黏附分子研究进展

Adhesion molecules related to metastasis in colon carcinoma

结肠癌是一种常见的恶性肿瘤，近年来我国该病的发病率上升十分明显，尽管诊疗水平有了很大提高，但肿瘤组织侵袭转移仍是患者死亡的主要原因。肿瘤的转移是多阶段多因素的过程，在这个过程中细胞黏附分子表达异常或功能丧失在肿瘤的转移中起着非常重要的作用。细胞黏附分子是由细胞合成的，介导细胞与细胞或细胞与基质间相互接触和结合的一类糖蛋白分子，主要参与细胞的信号传导与活化、细胞的伸展和移动、肿瘤转移、创伤愈合等一系列重要生理和病理过程。

Colon carcinoma is one of the most common malignant neoplasms. The incidence of this disease has been increasing significantly in recent years in China. Although diagnostic and therapeutic methods have been improved greatly, carcinoma invasion and metastasis are considered to be the main causes of poor prognosis and death. Tumor metastasis is a complicated process with multiple steps and factors. Cell adhesion molecule （CAM） play a very impntant role in this process while it expresses exceptionally or loses its function. CAM is a kind of glycoprotein molecule by the cell synthesis which mediates the intercontact and intereombination between cell and cell or between cell and matrix. It takes part in a series of important physiologic and pathologic processes, such as cell signal conduction and activation, cell extension and migration, tumor metastasis and wound healing, and so on.