摘要
目的探讨卡维地洛对急性心肌梗死PCI术后心功能不全患者QT间期离散度、室性心律失常及左室射血分数的影响。方法97例急性心肌梗死PCI术后LVEF<50%患者分为基础治疗组(A组48例)及基础治疗加卡维地洛组(B组49例),B组在基础治疗上加服卡维地洛片10mg,2次/d,疗程12周。治疗前后应用常规心电图、24h动态心电图和多普勒超声心动图,观测QTd、QTcd、心率、VA的发生情况以及LVEF的变化。结果B组QTd、QTcd及VA发生率均较A组明显下降(P<0.05),LVEF明显升高(P<0.05),而HR、BP无明显变化(P>0.05)。结论急性心肌梗死PCI术后心功能不全患者应用卡维地洛可通过缩短QTd、QTcd而降低心室肌复极的不均一性因此减少VA的发生率,明显提高LVEF,改善心功能状况,改善不良预后。
Objective To investigate the effect of Carvedilol on QT dispersion, ventricular arrhythmias（VA）and left ventricular ejection fraction（LVEF） in patients of acute myocardial infarction（AMI） with heart dysfunction after percutaneous coronary intervention（PCI）. Methods 87 patients of AMI after PCI with LVEF〈50% were divided into regular treatment group （A group, n= 43） and regular treatment combined with Carvedilol group（B group,n=4d）, which was treated with Carvedilol lOmg, bid on the basis of conventional therapy. All patients were followed up for 12 weeks and measured the changes of QTd, QTcd, HR,VA and LVEF by 12-lead electrocardiogram （ECG）, 24-hour dynamic electrocardiogram （Hottler） and echocardiography （ UCG ）. Results Compared with regular treatment group, QTd, QTcd and morbidity of VA in B group were significantly decreased（P 〈 0.05 ）, LVEF significantly increased（P 〈 0.05 ） and HR, BP did not change （P 〉 0.05）. Conclusion Carvedilol can diminish the dispersion of repolarization of ventricular myocardium by decreasing QTd, QTcd and morbidity of VA, elevate LVEF and improve cardiac function and prognosis.
出处
《中国现代医生》
2009年第6期17-18,共2页
China Modern Doctor
