摘要
目的研究良恶性胸腔积液多效蛋白(PTN)的表达,探讨多效蛋白对肺癌的诊断价值。方法分别采用双抗体夹心酶联免疫吸附实验法检测肺癌组50例、良性组50例患者胸腔积液中PTN、癌胚抗原(CEA)的表达水平。结果①恶性胸腔积液组PTN表达水平显著高于良性组([47.744±40.007)ng/mL vs(3.719±1.827)ng/mL,P<0.001],胸腔积液PTN含量测定对恶性胸腔积液的诊断效能略差于CEA。结论胸腔积液PTN对肺癌合并恶性胸腔积液有一定的诊断价值,PTN、CEA联合检测有助于临床诊断。
Objective To investigate the expression of Pleiotrophin in the pleural effusions of patients with benign and malignant diseases, carcinoembryonic antigen（CEA）, and to study the diagnostic vaule of Pleiotrophin for lung cancer. Methods Pleiotrophin, CEA levels in pleural effusions were measured respectively in benign diseases（n=50） and lung cancer patients（n=50） by using sandwich enzymelinked immunosorbent assay（ELISA）. Results The concentration of Pleiotrophin was significantly higher in malignant pleural effusions due to lung cancer（47.744 ± 40.007） than that in benign group（3.719 ± 1.827ng/ml）, P〈 0.001. Pleiotrophin was slightly less valuable than CEA in the diagnosis of malignant pleural effusions. Conclusion Pleiotrophin may be an useful marker to differentiate between benign and malignant pleural effusions. The combined detection of two indicators-Pleiotrophin,CEA in the pleural effusions were of important clinical significance in the diagnosis of lung cancer.
出处
《中国现代医生》
2009年第6期29-31,37,共4页
China Modern Doctor
关键词
胸腔积液
多效蛋白
肺癌
癌胚抗原
Pleural effusion
Pleiotrophin
Lung cancer
Carcinoembryonic antigen
