呼吸衰竭患者血清心肌酶谱变化的临床研究

Changes and Clinical Significance of Serum Enzyme Levels in Patients with Respiratory Failure

目的通过测定呼吸衰竭患者血清心肌酶谱变化,探讨其临床价值。方法应用自动生化分析仪测定呼吸衰竭患者与对照组(下呼吸道感染患者)的血清心肌酶浓度。结果呼吸衰竭组16例(21.5%)血清谷丙氨酸转移酶(ALT)值、48例(63.2%)血清天门冬谷草氨酸转移酶(AST)值、45例(59.2%)血清磷酸肌酸激酶(CK)值、21例(27.6%)血清乳酸脱氢酶(LDH)值、46例(60.5%)血清a-羟丁酸脱氢酶(HBDH)值、54例(71.1%)血清肌酸激酶同工酶(CK-MB)值均高于正常值上限。结论呼吸衰竭时AST、CK、HBDH、CK-MB明显升高,与对照组相比有显著差异;且血清心肌酶的变化和病情严重程度有关,病情越重,低氧症状越重,心肌酶升高幅度越大,病死率越高。血清心肌酶明显增高,是病情危重的信号,应引起临床医师重视。

Objective To study the value of serum enzyme in patients with respiratory failure in hospital. Methods The levels of serum enzyme in patients with respiratory failure and the controls（general pneumonia） were quantitatively detected by automatically partielc enhanced immunoturbidimetric assay. Results Serum ALT level showed an increase in 16 （21.5%） of the patients with respiratory failure, serum AST level increased in 48（63.2%）, serum CK level increased in 45（59.2%）,serum LDH level increased in 21 （27.6%）,serum HBDH level increased in 46（60.5%）and serum CK-MB level increased in 54（71.1%）. Conclusion As respiratory failure is getting worse serum levels of AST CK HBDH CK-MB were seen in gradual increase and the levels in respiratory failure was significantly higher than those of the eontrol group. It thus should be taken into consideration by clinieians.