摘要
目的探讨术前新辅助化疗PF(DDP+5-FU)方案对进展期食管癌近、远期疗效的影响。方法对术前临床分期为Ⅱ、Ⅲ期,未行放化疗、无手术禁忌证的300例食管癌患者进行分组研究。实验组96例,术前行DDP80mg/m2·d1,5-Fu100mg/m2·d1-5方案化疗,间隔2～4周,连续2个疗程。化疗结束2～4周后手术。对照组204例,术前未行任何治疗直接手术。对两组病例近、远期疗效进行比较分析。结果实验组术后局部复发率较对照组降低,但无统计学意义;术中出血量、术后拔除胸引管时间、术后吻合口瘘率两组无明显差异。实验组中的1、3、5年生存率分别为60.42%、43.75%、35.42%,对照组1、3、5年生存率分别为48.04%、31.37%和26.47%。两组的K-M生存曲线1、3年的差异有显著性(P<0.05),5年无明显差异(P>0.05)。结论术前化疗能降低肿瘤分期、局部复发率;亦可提高1年和3年生存率,但远期生存效果仍不明确。
Objective To explore the efficacy of preoperative chemotherapy followed by surgery for the advanced esophageal carcinoma. Methods 96 patients were treated preoperative chemotherapy of PF （DDP 80mg/m^2·dl; 5-Fu 500mg/m^2·d1-5） 2 cycles before surgery（group A） or immediately surgery（group B）. The efficacy of two treatment group was analyzed. Results The 1-year and 3-years survival rates of group A and group B were 60.42% ,43.75% and 48.04% ,31.37%. It was a significant increase. The postoperative local recurrence rate of group A was lowered. But there were no significant differences in complications and 5-years survival rate between two groups. Conclusion Preoperative chemotherapy with PF increased 1 and 3-years survival rate of the advanced esophageal carcinoma by lowered the local tumor stage.
出处
《中国现代医生》
2009年第8期9-10,15,共3页
China Modern Doctor
关键词
进展期食管癌
生存率
术前化疗
Advanced esophageal cancer
Survival rate
Preoperative chemotherapy
