心肺骤停早期应用氨茶碱对临床复苏效果的影响

The Clinical Study of Aminophylline Applied for Cardiac Arrest in Early Phase

目的观察腺苷受体拮抗剂氨茶碱在心肺脑复苏中的作用。方法将我院急诊科2001年3月～2008年3月收治的152例心脏骤停患者分为氨茶碱复苏组和传统复苏组。氨茶碱复苏组75例,采用复苏早期应用氨茶碱、肾上腺素和阿托品等;传统复苏组77例,采用静脉推注肾上腺素、阿托品等传统复苏方法。观察两组心电活动、自主呼吸和自主循环的恢复情况,比较两组心肺复苏成功率的差异。结果氨茶碱复苏组心电活动、自主呼吸和自主循环的恢复率以及心肺复苏成功率均高于传统复苏组,差异具有显著性(P<0.05)。结论心肺骤停早期应用氨茶碱可促进患者心电活动、自主呼吸和自主循环的恢复,有助于提高心肺复苏成功率。

Objective To investigate the effects of aminophylline applied for cardiac arrest in early phase. Methods 152 cases with cardiac arrestwere ramdomly divied into two groups, including the patients treated with aminophylline group（Aminophyllinegroup, n=75）and the patients treated by the routine methods group （Routinegroup,n--77）. Patients in the aminophyUinegroup were treated with aminophylhne, epinephrine and atropine in combination, while patients in the routinegroup treated only with epinephrine and atropine. The recovery of cardiac electrical activity,spontaneous breath and spontaneous circulation were observed,and the rate of succesful cardiopulmonary resuscitation, especially,the rate of cardiopulmonary cerebral resuscitation were compared. Results The aminophyllinegroup received more satisfactory recovery of cardiac electrical activity,spontaneous breath and spontaneous circulation than the routinegroup.Similarly,the rate of succesful cardiopulmonary resuscitation,especially,the rate of cardiopulmonary cerebral resuscitation,were higher in the aminophyllinegroup than in the routine group（P〈0.05）. Conclusion Aminophylline can be applied for cardiac arrest as the assistant drugs in early phase, with the satisfactory recovery of cardiac electrical activty,spontaneous breath and spontaneous circulation and the promoted rate of satisfactory cardiopulmonary cesuscitation.