大剂量谷维素与门冬氨酸钾镁配伍治疗心律失常的临床研究

The Combination of Amount Oryzanol with Potasium Magnesium Aspartate in the Treatment of Arrhythmias

目的探讨大剂量谷维素与门冬氨酸钾镁联用治疗心律失常的疗效。方法将无房室传导阻滞的97例心律失常患者随机分为两组,对照组46例,仅口服乙氨碘呋酮,200mg/次,3次/d;治疗组51例,在对照组用药的基础上静脉滴注门冬氨酸钾镁注射液200mL,1次/d;口服谷维素,100mg/次,3次/d。两组疗程皆10d,治疗前后均经12导联心电图记录及血压、血脂检测。治疗过程中每两日记录一次心电图。结果治疗组总效率为90.2%,而对照组为61%,两者比较其差异均有显著性(P<0.01)。治疗组血清胆固醇降低治疗前后比较具显著性差异(P<0.01)。结论谷维素与门冬氨酸钾镁对心脏皆有着较广泛作用,两药联合从不同环节对心律失常发挥治疗作用,有着较佳疗效,安全方便、价廉,患者易接受,且未见明显不良反应,是一种治疗心律失常的较佳方法。

Objective To explore the therapeutic effect of combining amount oryzanol with potasium magnesium aspartate the treatment of arrhythmias. Methods The 97 patients without atrial-ventricl bloker in arrhythmias are randomly divided into two groups. The control group which has 46 cases is given oral Amiodarone 200mg three times daily; The treatment group which has 51 cases is given potasium magnesium aspartatein 20ml with intravenous,once daily based on the same therapy used in the control group. Both have this for ten days, as a course of treatment. Changes of 12 lead Electrocardiogram（ECG）, blood pressure and blood fatty, before and after treatment are evaluated. The two groups have ECG once in two days dring a course of treatment. Results The total effective rate was 90.2% of the treatment group,while the control group was 63.05%,compared with those treatment and in the control group all showed difference was significant （P〈0.O1）,and two dungs reduced serum cholesterol,the difference before and after was significant （P 〈 0.01）. Conclusion Oryzanol and potasium magnesium aspartate have wide function for the heart. Combining them,the function is great,as they have better effect on heart curation on different aspects. This method was safe,convenient and cheap,easily accepted by the patients and has no obvious side effects. It＇s comparatively a good method to treat arrhythmias.