硫酸氢氯吡格雷与阿托伐他汀钙联合治疗急性冠脉综合征

Discussion of Clopidogrel Combined Atorvastatin in Treatment of Acute Coronary Syndrome

目的探讨硫酸氢氯吡格雷联合阿托伐他汀钙治疗急性冠脉综合征的临床疗效。方法选择60例急性冠脉综合征患者,随机分为常规治疗组和联合治疗组,观察两组治疗前后患者空腹血清高敏C反应蛋白及血脂的变化。结果联合治疗组治疗后检测hs-CRP与常规治疗组相对比下降幅度有非常显著性差异(P<0.01);联合治疗组治疗后检测血脂水平与常规治疗组相对比下降幅度有显著性差异(P<0.05)。结论硫酸氢氯吡格雷联合阿托伐他汀钙治疗ACS患者,除抑制血小板聚集外,还有独立的抗炎作用,是一种有效的治疗手段。

Objective To evaluate the clinical effect of clopidogrel and atorvastatin in patients of acute coronary syndrome. Methods With methods of random grouping, 60 patients of acut coruonary syndrome were divided into routine treatment group and combined treatment group, change of fasting serum high sensitive C-reative protein and serum lipid were observed in all patients of two groups pre and post treatment. Results After treatment,there were very significant difference（P〈 0.01 ） between the descent range of hs-CRP of routine treatment group and combined treatment group, there were significant difference（P〈 0.05 ） between the descent range of serum lipid of the two groups. Conclusion Clopidogrel combined with atorvastatin can inhibit platelet aggregation and has an independent anti-inflammatory effect.