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晚期糖基化终产物及其受体与糖尿病相关神经系统疾病 被引量：4

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摘要 此文概述了糖尿病状态下晚期糖基化终产物(AGEs)及其受体在神经系统中的表达和分布,AGEs对糖尿病神经系统损害及其在糖尿病神经系统并发症发生发展中的作用和机制,以及阻断晚期糖基化终产物及其受体的药物。
作者 余爱勇 赵玉武
机构地区 上海交通大学附属第六人民医院神经内科
出处 《中国神经免疫学和神经病学杂志》 CAS 2009年第2期141-143,147,共4页 Chinese Journal of Neuroimmunology and Neurology
关键词 晚期糖基化终产物 晚期糖基化终产物受体 糖尿病相关神经系统疾病
分类号 R745.49 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献18

  • 1Creager MA, Luscher TF TF,Cosentino F, etal. Di- abetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: Part I[J].Circulation, 2003,108(12) :1527-1532.
  • 2Aragno M, Mastrocola R, Medana C, et al. Oxida rive Stress-Dependent Impairment of Cardiac-Specific Transcription Factors in Experimental Diabetes [J].Endocrinology, 2006,147(12) :5967-5974
  • 3Bierhaus A,Schiekofer S,Schwaninger M, et al. Diabetes-associated sustained activation of the transcription factor nuclear factor-kappa B[J].Diabetes,2001, 50(12):2792 -2808.
  • 4Haslbeck KM, Schleicher ED, Friess U, etal. N(ep silon)-Carboxymethyllysine in diabetic and non-diabetic polyneuropathies[J]. Acta Neuropathol, 2002,104 (1) : 45-52.
  • 5Toth C, Rong LL, Yang C,et al. Receptor for advanced glycation end products (RAGEs) and experimental diabetic neuropathy[J].Diabetes, 2008,57 (4) :1002-1017.
  • 6Vincent AM, Perrone L, Sullivan KA,et al. Receptor for advanced glycation end products activation injures primary sensory neurones via oxidative stress[J]. Endocrinology, 2007 ,148(2) ;548-558.
  • 7陆邦超,王坚.晚期糖基化终产物及其受体在糖尿病周围神经病变中的作用[J].中国神经免疫学和神经病学杂志,2007,14(6):367-369. 被引量：11
  • 8Eaton SE, Harris ND, Rajbhandari SM,etal. Spinal cord involvement in diabetic peripheral neuropathy [J]. Lancet,2001, 358(9275): 35-36.
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二级参考文献12

  • 1潘晓东,陈晓春.非酶糖化、晚期糖基化终产物与阿尔茨海默病[J].国际神经病学神经外科学杂志,2005,32(4):334-337. 被引量：2
  • 2Kikuchi S, Shinpo K, Takeuchi M, et al. Glycation-a sweet tempter for neuronal death[J]. Brain Res Reviews, 2003, 41:306-323.
  • 3Stracke H, Hammes HP, Werkmann D, et al. Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats [J]. Exp Clin Endocrinol Diabetes, 2003,109:330-336.
  • 4Haslbeck KM, Schleicher ED, Friess U, et al. N(epsilon)-Carboxy-methyllysine in diabetic and non-diabetic polyneuropathies[J]. Acta Neuropathol, 2002, 104:45-52.
  • 5Wada R, Nishizawa Y, Yagihashi N, et al. Effects of OPB-9195, anti-glycation agent,on experimental diabetic neuropathy[J]. Eur J Clin Invest,2001,31:513-520.
  • 6Poirier O, Nicaud V, Vionnet N, et al. Polymorphism screening of four genes encoding advanced glycation end-product putative receptors.Association study with nephropathy in type 1 diabetic patients[J].Diabetes, 2001,50:1214-1218.
  • 7Takeuchi M. Neurotoxicity of advanced glycation end-products for cultured cortical neurons[J]. J Neuro-pathol Exp Neurol,2000,59:1094-1105.
  • 8Sekido H, Suzuki T, Jomori T, et al. Reduced cell replication and induction of apoptosis by advanced glycation end products in rat Sehwann cells[J]. Bioehem Biophys Res Commun, 2004,320:241-248.
  • 9Bierhaus A, Schiekofer S, Schwaninger M, et al. Diabetes-associated sustained activation of the tran-scription factor nuclear factorкB[J].Diabetes, 2001, 50:2792-2808.
  • 10Flatters SJ, Fox AJ, Dickenson AH, et al. Nerve injury alters the effects of interleukin-6 on noeieeptive transmission in peripheral afferents[J].Eur J Pharmacol,2004, 484:183-191.

共引文献10

同被引文献48

引证文献4

二级引证文献14

中国神经免疫学和神经病学杂志
2009年 第2期

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