褪黑素合成及环化机理研究

Study of synthesize melatonin and cyclic reaction mechanism

以邻苯二甲酰亚胺钾盐为起始原料,经五步反应合成了褪黑素,鉴定了产物结构,合成收率达35.6%,纯度99.1%。对中间产物2-羧乙酯基-3-(2-邻苯二甲酰亚胺乙基)-5-甲氧基-吲哚的环化反应过程进行了机理研究,为最佳工艺条件的确定提供了理论依据。

This paper reported synthesis of melatonin by five-step reaction route with K-phthalimide, the product was determined ,the overall yield is 35.6%, product purity over 99.1%. The paper studied the cyclic reaction mechanism of 2-ethoxycarbonyl-3- （2-phthalimidoethyl） -5-methoxy-indole, provided of theoretical for optimum condition.