不同NMA源对肥育猪血清激素水平及代谢指标的影响

Effect of different types of N-methyl-D-aspartate (NMA) on hormone level and metabolism parameters in serum of finishing pigs

本试验旨在研究不同N-甲基-D-天冬氨酸(NMA)源对肥育猪血清激素水平及代谢指标的影响。选用120头体重60kg左右的杜长大三元杂交肥育猪,随机分为4个处理,处理1为对照组,处理2、3、4组分别添加100 mg/kg普通型、吸附型(纳米硅酸盐为载体)和钠米型(纳米级)NMA。试验结果表明:与对照组相比,试验组猪血清生长激素和胰岛素样生长因子-I水平均较对照组有一定的提高,以100 mg/kg纳米型NMA效果最为显著,分别提高了41.01%(P<0.05)和21.91%(P<0.05)。吸附型和纳米型NMA均显著提高血清三碘甲腺原氨酸(FT3)和四碘甲腺原氨酸(FT4)水平,其中FT3较对照组分别提高了51.79%(P<0.05)和60.71%(P<0.05),FT4提高了200.75%(P<0.05)和236.48%(P<0.05)。血清相关代谢指标分析显示,不同形式NMA对肥育猪血清尿素氮、葡萄糖和总蛋白浓度产生了一定的影响,以纳米型NMA效果最为显著,尿素氮较对照组降低了13.96%(P<0.05),葡萄糖浓度增加了16.92%(P<0.05),总蛋白提高了11.22%(P<0.05)。本研究结果表明,纳米型NMA可显著促进猪生长激素和胰岛素样生长因子-I的合成与分泌,提高育肥猪的代谢水平,从而促进了育肥猪的生长发育。

Effects of different types of N methyl-D-aspartate （NMA） on hormone level and biochemical index in serum of finishing pigs were studied. One hundred and twenty finishing pigs （Duroc× Landrace × Yorkshire） with an average initial weight of 60 kg were allotted to four groups. Group 1 was the control group, group 2,3 and 4 were added 100 mg/kg NMA of ordinary NMA （O-NMA） ,adsorbed NMA （A-NMA） and nano NMA （N-NMA） ,respectively. The results showed that N-NMA enhanced GH and IGF-I concentration by 41.01%（P〈0.05）and 21.91% （P〈0.05） ,respectively. A-NMA and N-NMA increased FT3 by 51.79G （P〈0.05）and 60.71% （P〈0.05）,and improved FT4 by 200.75 % （P〈0.05）and 236.48 % （P〈0.05）respectively. Adding NMA has no obvious effect on insulin concentration. Compared with the control group, N-NMA group decreased serum urea nitrogen by 13.96 % （P 〈0.05） ,and increased serum glucose and total protein concentration by 16.92% and 11.22% （P%0.05）, respectively. N-NMA is beneficial to improve growth performance by stimulating GH and IGF-I secretion and influencing metabolism parameters of serum in finishing pigs.