对羧基苯基膦酸的合成

Synthesis of the p-carboxyphenyl phosphonic acid

以对氨基苯甲酸、亚硝酸钠、浓硫酸为原料,经重氮化、桑德迈耶反应、酯化反应、水解反应合成了标题化合物,收率82%。通过元素分析、红外光谱、核磁共振谱和质谱确证了中间体及目标产物的结构。

A novel compound p-carboxyphenyl phosphonic acid was synthesized by using p-aminobenzoic acid,sodium nitrite and concentrated sulfuric acid as the starting materials via the diazotization reaction,the Sandmeyer reaction,esterification and the hydrolysis reaction.The yield of the target product was up to 82%,and the structures of the intermediate and the target compound were characterized by IR,1HNMR,13CNMR and elemental analyses.