p-p38和VEGF在原发性肝癌中的表达及相关性研究

Correlation between expression of p-p38 and VEGF in primary hepatocellular carcinoma

目的研究磷酸化p38(p-p38)和血管内皮生长因子(VEGF)在原发性肝癌中的表达及与临床病理特征的关系。方法采用免疫组织化学S-P法,检测53例原发性肝癌组织,30例非癌肝组织中的p-p38和VEGF表达情况并分析其相关性及临床病理特征。结果p-p38和VEGF阳性表达率在原发性肝癌组织明显高于非癌肝组织,与患者年龄、性别、病理分型、肿块最大径等临床病理特征参数没有相关性。但与肝癌的转移、癌栓、组织分化程度有相关性,p-p38和VEGF在肝癌中的表达呈正相关r=0.458(P=0.001,P<0.05)。结论p-p38和VEGF过表达在肝癌的发展及浸润转移中具有重要作用。

objective To investigate the expression of phosphorylated p38MAPK （p-p38） and Vascular endothelial growth factor （VEGF） in primary hepatocellular carcinoma,and study on correlation between p-p38, VEGF and clinicopathologic features.Methods Using S-P immunohistochemical method to detect the expression of p-p38 and VEGF in 53 hepatocellular carcinoma tissues,30 paracancerous tissues.Results The positive rates of p-p38 and VEGF in the tissues of hepatocellular carcinoma were significantly higher than those in paracancerous tissues.Expression of p-p38 and VEGF were significandy correlated with tumor metastasis,cancer embolus and pathological grade.There were not correlated with age,gender, serum concentration of AFP,pathological type and tumor size.There was a positive correlation between the expression of p-p38 and VEGF in hepatocellular carcinoma （r=0.458,P=0.001）.Conclusion p-p38 and VEGF gene might play an important roles in the progression and metastasis of hepatoeellular carcinoma.