摘要
以2-甲基萘为原料,在惰性的卤代烃溶剂中低温下进行溴化反应,制备1-溴-2-甲基萘;溴化产物在碘化亚铜催化下,和甲醇钠进行烷氧基化反应制得1-甲氧基-2-甲基萘。产品纯度﹥99%(GC),总收率87.4%,产品结构经MS和1H NMR确认。考察了反应条件对产品收率和纯度的影响。
Bromination of 2-methylnaphthalene at low temperature gave 1-bromo-2-methylnaphthalene （I）. 1- Methoxy-2-methylnaphthalene was obtained from reaction of I with sodium methoxide catalyzed by CuI. The process gave an overal yield of 87.4%. The product was characterized by MS and ^1H NMR.
出处
《精细化工中间体》
CAS
2009年第1期39-41,共3页
Fine Chemical Intermediates
