摘要
利用磁性传感器,特别是GMR传感器,对生物特异性反应进行检测,从而解决传统荧光检测存在的标记易失、可重复性差,对设备和技术人员要求高等缺点。采用超顺磁磁珠作为磁性标记物,将其与被测生物分子充分结合后固定在芯片表面,再通过磁阻传感器的磁阻变化检测磁性标记的存在。采用高灵敏度的GMR传感器和磁性含量高的磁性颗粒,减小标记与传感器之间的距离和尺度差异,能提高阵列生物检测性能。将GMR传感器阵列应用在生物检测上是极具发展前途的研究方向,通过对已有方案的改良或选用新型的材料,最终会实现磁性生物传感器灵敏、快速、便捷的实际应用。
Fluorescence - based DNA microarray systems often need prohibitively high cost of associated equipment and the fluorescent labels are photo - sensitive and bleach out when exposed to light. The biodetection technology based on GMR sensors and the performance of these sensors array are intrduced. Employing superparamagnetic magnetic particles as labels, the target molecules in sample solution are captured on to the surface by biomolecular recognition. The sensors detect the presence of the magnetic labels via a change in sensor resistance. In order to improve the performance of GMR biosensor array, it is important to develop high sensitivity sensor,high content magnetic particles and decrease the distance and variation of size between sensors and magnetic particles. GMR biochips represent a rapidly expanding research area, and new designs which overcome these limitations and employ new material can improve their practical sensitivity, fastness and convenience.
出处
《现代电子技术》
2009年第6期190-194,共5页
Modern Electronics Technique
