系统性红斑狼疮患者T细胞亚群临床研究

CLINICAL STUDY OF T CELL SUBPOPULATION IN PERIPHERAL BLOOD OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

目的探讨并分析SLE(系统性红斑狼疮)患者外周血T细胞亚群占CD4+T细胞的百分比,以阐述其临床意义。方法流式细胞术检测34例SLE初诊、20例复发和35例治疗后病例外周血T细胞亚群占CD4+T细胞的百分比,并以39例健康体检者作为正常对照,同时观察上述检测指标与SLEDAI(狼疮活动指数评分)、GLB(血清球蛋白)、IgG(免疫球蛋白)、ESR(血沉)、C3、C4的关系。结果SLE初诊患者外周血T细胞亚群占CD4+T细胞的百分比显著低于复发、治疗后及正常对照组(p<0.01),活跃期亦显著低于稳定期(p<0.05),与ESR、GLB、C3、C4、IgG有相关性。结论T细胞亚群改变可能是导致SLE发生和病情发展的关键。

Objective To explore the clinical significance by investigating and analyzing the percentage of T cell subpopulation in CD4＋ T cell in the peripheral blood of patients with SLE. , Methods Thirty - four SLE patients of preliminary diagnosis and twenty SLE patients of relapse and thirty - five SEL patients of post - treatment and thirty- nine healthy individuals were studied,the percentage of T cell subpopulation in CD4＋T cell in the peripheral blood was detected by flow cytometry （ FCM ）, the relationship of ESR, GLB, C3, C4, IgG and the percentage of T cell subpopulation were observed. Results Compared with another three cases , the percentage of T cell subpopulation in CD4 ＋ T cell from thirty - four SEL patients of preliminary diagnosis was the lowest （p 〈 0.05 ） , so is in active stage, significant correlation was found between the levels of the percentage of T cell subpopulation in CD4＋ T cell and other serological parameters including ESR, GLB, C3, C4, IgG. Conclusion T cell subpopulation may play an important role in the pathogenesis and progression of SLE.