睾丸神经内分泌癌的临床病理分析

Clinic pathology analysis of small cell carcinoma of testis

目的探讨睾丸小细胞神经内分泌癌的临床病理特征和生物学行为。方法回顾分析睾丸小细胞神经内分泌癌1例并复习有关文献予以讨论。结果患者术前未得到明确的病理诊断,术后2周恢复良好,痊愈出院。出院3周后右腋窝淋巴结转移,7周后全身转移死亡。病理检查:肿瘤细胞表达神经内分泌标记物神经原特异性烯醇酶、嗜铬粒蛋白A和突触素。结论睾丸小细胞神经内分泌癌是一种比较少见的高度恶性肿瘤,有独特的病理形态,早期即可发生转移,预后凶险,死亡率高。

Objective To study the clinical histological and immunohistochemical characteristics of small cell neu-roendocrine carcinoma（SCC）of the testis and biological behavior.Methods One case of testis neuroendocrine carcinoma was analyzed retrospectively.Results Definite pathologic diagnosis in the case wasn＇t confirmed before operation.The patient recovered well two weeks after operation;but 3 weeks later,the tumor had metastasized to the right nodi lymphatici axillares;7 weeks later,the patient died of the tumor for metastases all over the body.By pathological examination the neuroendocrinic markers,such as NSE,CgA,and Syn were expressed in the tumor cell.Conclusion SCC of the testis is rare and highly malig-nant tumor with distinct pathological features.It is aggressive with early metastases and has a poor prognosis and high mortality.