帕罗西汀并康复训练治疗脑卒中后抑郁患者疗效观察

The effect of paroxetine combined with rehabilitation on patients with depression after stroke

目的探讨帕罗西汀+康复治疗方法对卒中偏瘫抑郁患者的疗效。方法123例大脑半球卒中后抑郁患者分为帕罗西汀治疗组(A组)、帕罗西汀+康复治疗组(B组)及对照组(C组)。A组在常规卒中治疗同时加用帕罗西汀口服,B组在前者基础上加用康复干预,C组仅给与常规卒中治疗,对3组患者抑郁状态、运动功能、日常生活活动能力进行定期观察。结果治疗前3组间HAMD、FMA、ADL评分差异无统计学意义。在治疗2周、4周后,A组和B组各项评分均优于C组,差异具有统计学意义,但A组与B组之间差异无统计学意义。在治疗8周后A组和B组各项评分仍均优于对照组,且B组各项评分优于A组,差异有统计学意义。结论帕罗西汀治疗卒中后抑郁疗效显著;帕罗西汀配合康复训练比单独应用帕罗西汀更加有效。

Objective To observe the effect of rehabilitation and paroxetine therapy on the stroke patients with de-pression.Methods 123 cerebral stroke patients with depression were divided into 3 groups,which including 39 patients in group A（paroxetine therapy）,43 patients in group B（paroxetine and rehabilitation therapy）and 41 patients in group C（rou-tine stroke therapy without paroxetine and rehabiltation）.Activities of daily living（ADL）,Hamilton depression rating scale（HAMA）,Fugl-Meyer assessment（FMA）and Modified Barthel Index（MBI）were assessed in each patients at the time of second,fourth and eighth week after stroke.Results In the 2nd,4th and 8th week after stroke,the patients were significant improved in group A and B as compared with group C based from the assessment of the above tests.Conclusion Therapy with paroxe-tine,or paroxetine combined with rehabilitation have obviously therapeutic effect on depression after stroke.