黄葵胶囊联合氯沙坦治疗糖尿病肾病的临床研究

Clinical Research of Combination Therapy with Abelmosehus Moschatus and Losartan for Diabetic Nephropathy

目的探讨黄葵胶囊与氯沙坦联合对糖尿病肾病的治疗作用。方法60例糖尿病肾病患者在积极治疗原发病的基础上,随机分为联合治疗组和氯沙坦组,每组各30例,联合治疗组给予黄葵胶囊与氯沙坦联合治疗,氯沙坦组给予氯沙坦单独治疗。在治疗前、后检测尿白蛋白排泄率(UAER),尿β2微球蛋白(β2-MG),空腹血糖(FBG),血清TC、TG及BUN、Scr等指标。结果联合治疗组和氯沙坦治疗组经治疗后UAER、FBG、尿β2-MG、血脂及BUN、Scr等相关参数均有明显改善,差异具有显著性(P<0.05或P<0.01),联合治疗组优于氯沙坦治疗组(P<0.05)。结论黄葵胶囊联合氯沙坦治疗糖尿病肾病有相互协同的作用,疗效优越,值得临床推广。

Objective： To investigate the curative effects of abelmosehus moschatus and losartan for diabetic nephropathy. Methods： 60 pa tients with diabetic nephropathy were divided into two groups： combined treatment group and losartan group with 30 cases in each group. The patients were treated with abelmosehus moschatus and losartan in combined treatment group. The patients were treated with losartan in the other group. Then the levels of UAER, β 2-MG, FBG, TC, TG and BUN, Scr were detected before and after the treatment. Results： The levels of UAER, β 2-MG, FBG, TC, TG and BUN, Scr of the patients were obviously decreased in two groups（P〈0.05 or P〈0. 01）. The data of combined treatment group were better than those of the losartan group（P 〈0.05）. Conclusion ： The combined treatment of abel mosehus moschatus and losartan is effective in diabetic nephropathy.