扩张型心肌病发病机制新论

The New Mechanical Infer of Dilated Cardiomyopathy

扩张型心肌病严重影响患者的心功能和生存率,目前除心脏移植外尚无很好的治疗方法,多年来一直是困扰临床医学的一个难题。目前临床医学采用的治疗措施主要是依基因缺陷、病毒感染和自身免疫等因素诱发的心肌变性、坏死和纤维化导致心脏扩大和心功能衰竭为理论基础的发病机制学说。通过多年的临床观察和研究我们发现这一理论可能存在与临床病理变化不一致的方面,为此我们提出扩张型心肌病的基因缺陷、感染和自身免疫等因素首先导致心脏骨架结构的损害和扩大,进而发生心肌细胞的变性、坏死和纤维化过程,最后导致心功能降低和心力衰竭。

Dilated cardiomyopathy seriously influences the heart function and survival rate. At present except heart transplantion there is no good treatment. It is a very difficult clinical question. Now clinical treating methods mainly depend on theoretic foundation of heart expanding and failure causing by cardiac denaturation, necrosis and fibrosis leading by gene defect, virus infection and self-immunity et cetera. By clinic observation and study we recognize that this theory is inconsequent to clinical pathology. So we propose that gene defect, virus infection and self-immunity et cetera factors of dilated cardiomyopathy firstly bright on the lesion and expanding of cardiac framework, then happen cardiac denaturation, necrosis and fibrosis, at last lead to cardiac function lowing and heart failure.