期刊文献+

基于微阵列生物传感器的CMOS恒电位仪的设计

Design of CMOS potentiostat based on microarray biosensor
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摘要 针对1×4的生物传感器阵列,设计了一种CMOS恒电位仪电路。采用了一种所有运算放大器共享同一运放的左半边电路的恒电位仪结构,极大地减少了读出电路的功耗与芯片版图的面积。在0.6μmCMOS工艺下,用Spectre仿真器对该电路进行了模拟,仿真结果表明:运用该恒电位仪的电流积分电路使传感器的输入输出转换具有良好的线性关系和较宽的动态响应范围。 Aimed at a 1×4 biosensor array, a CMOS potentiostat circuit is designed. A potentiostat structure is used that shared a common half circuit among all of the amplifiers,layout area and power consumption of readout circuit are reduced. Simulation is carried out with 0.6μm CMOS process by Spectre emulator. The simulation results show that good linear relation between input and output and broad dynamic respond range of biosensor is obtained by using current integral circuit with potentiostat.
出处 《传感器与微系统》 CSCD 北大核心 2009年第3期80-82,85,共4页 Transducer and Microsystem Technologies
基金 重庆市自然科学基金资助项目(2007BB2176)
关键词 生物传感器 恒电位仪 运算放大器 biosensor potentiostat operational amplifier
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参考文献8

  • 1贺敏娟,崔华莉.微阵列电化学生物传感器研究进展[J].现代生物医学进展,2006,6(8):66-68. 被引量:6
  • 2黄钦文,李斌,黄美浅,刘仲明,刘芳.微阵列电极电化学生物传感器[J].传感器技术,2004,23(2):1-3. 被引量:10
  • 3Lu R, Yu T. Fabrication and evaluation of an oxygen microelectrode applicable to environmental engineering and science [ J ]. Journal of Environmental Engineering and Science, 2002 ( 1 ) : 225 --235.
  • 4Chao Bian,Xia Shanhong ,Xu Yuanyuan,et al. A micro amperometric immunosensor based on two electrochemical layers for immobilizing antibody [ J ]. Sensors, 2005 IEEE, 2005 ( 11 ) : 416 - 419.
  • 5Beach R D, Conlan R W, Godwin M C, et al. Towards a miniature implantable in vivo telemetry monitoring system dynamically configurable as a potentiostat or galvanostat for two-and three-electrode biosensors[ J]. Instrumentation and Measurement, IEEE Transactions on,2005.54( 1 ) :61 --72.
  • 6Bott A W. Electrochemical techniques for the characterization of redox polymers[ J]. Current Separations ,2001,19 (3) :71 -75.
  • 7Rezaul H S M. Stability analysis and novel compensation of a CMOS current-feedback potentiostat circuit for electrochemical sensors[ J]. Sensors Journal, IEEE ,2007,7 (5) :814 -- 824.
  • 8Hsieh C C, Wu C Y, Jih F W, et al. Focal-plane-arrays and CMOS readout techniques of infrared imaging systems [ J ]. IEEE Trans Circuits Syst Video Technol, 1997,7 (5) :594 -605.

二级参考文献24

  • 1朱建中.生物电化学传感器的微型化集成化和智能化[J].化学传感器,1994,14(1):1-6. 被引量:4
  • 2漆红兰,张成孝.纳米粒子在电化学DNA生物传感器研究中的应用[J].化学进展,2005,17(5):911-915. 被引量:6
  • 3廖鹏飞,夏金兰,聂珍媛,谢建平.磁性微球的制备及在生物分离应用中的研究进展[J].生物磁学,2005,5(4):47-51. 被引量:29
  • 4Ahuja SK,Ferreira GM,Moreira AR.Utilization of enzymes for environmental applications[J].Crit Rev Biotechnol,2004,24(2-3):125-54
  • 5Qari MH,High throughput coagulation analyzers review[J].Comb Chem High Throughput Screen.2005,8(4):353-60
  • 6Wick I,Hardiman G,Biochip platforms as functional genomics tools for drug discovery[J].Curr Opin Drug Discov Devel.2005,8(3):347-54
  • 7Schasfoort RB,Proteomics-on-a-chip:the challenge to couple lab-on-a-chip unit operations[J].Expert Rev Proteomics.2004,1(1):123-32
  • 8Orazio PD,Biosensors in clinical chemistry[J].Clin Chim Acta.2003,334:41-69
  • 9Turner PF.Biosensors--Sense and Sensitivity[J].Science,2000,17,290:1315-1317
  • 10Joerg A,Grunwald T,Nebling E,et al.Electrical biochip technology-a tool for microarrays,and continuous monitoring[J].Anal Bioanal Chem,2003,377:521-527

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