咽部感染细菌L型培养的临床意义

Pharyngeal Bacterial Infection in Cultured L-clinical Significance

目的明确细菌L型的检出情况及其在咽部感染中的致病作用，指导临床合理用药。方法采集2007年8月-2008年11月76例咽部感染的分泌物和50例正常人咽部分泌物作为标本进行细菌型培养鉴定；细菌L型培养鉴定；耐药性监测。结果76例咽拭标本细菌L型及细菌型培养情况：本组L型总检出率为86．8％，正常组检出率为52％。两组比较有显著差异（P〈0．05）；细菌型（17．1％）和混合型（13．2％）的检出率分别与正常组比较差别无显著性（P〉0．05）。细菌L型和返祖菌药敏结果比较：细菌L型对氯霉素、先锋霉素V（头孢唑啉）比返祖菌敏感，返祖菌对丁胺卡那霉素比细菌L型敏感。其余抗生素对两种菌的药物敏感性无大的差异。结论临床在使用抗生素时要兼顾细菌L型和细菌型，合理使用抗生素，以达到提前治疗效果，控制咽部感染反复发作的目的。

Obieetive A clear detection of bacterial L-type and their infection in the pharynx of the pathogenic role in guiding the clinical rational drug use. Method acquisition in August 2007 -2008 in November 76 cases of pharyngeal infection in 50 cases of normal secretions and pharyngeal secretions as type specimens for bacteriological culture identification; bacterial L-train identification; resistance monitoring. Results 76 cases of pharyngeal swab specimens of bacteria and bacterial L-type culture situation： The L-type total detection rate of 86.8%, normal detection rate of 52%. Comparing the two groups were significantly different （P 〈0.05）; bacterial type （17.1%） and mixed type （13.2%） of the detection rates were compared with .the normal group the difference was not significant （P〉 0.05）. Bacterial L-type and drug susceptibility throwback bacteria results： L-type bacteria to chloramphenieol, adriamycin Pioneer V （cefazolin） than in sensitive bacteria throwback, throwback strains to amikacin than the bacterial L - sensitive. The remaining two types of antibiotics on the drug sensitivity of bacteria are no major differences. Conclusions The clinical use of antibiotics in bacteria when to strike a balance between L-and bacteria-based, rational use of antibiotics in order to achieve early treatment effect, control recurrent throat infection purposes.