摘要
本文对正常人，器质性和精神性阳萎病人进行了研究，在阴茎勃起前后；测定阴茎海绵体内血浆中VIP浓度。对各组受检者行海绵体内注射生理盐水；盐酸罂粟碱，盐酸罂粟碱和酚妥拉明混合液体，每次注射药物间隔时间达30min以上，于海绵体内注射药物前后抽取海绵体内血液，测定血浆中VIP的含量。正常人及各类阳萎病人，在阴茎海绵沐内注射血管活性药物后，所有阴茎发生了勃起，在阴茎勃起过程中，海绵体内血浆中VIP浓度显著升高（P＜0．01）。同时，周围静脉内注射罂粟碱和酚妥拉明混合液体的受检者，在静脉注射药物后；周围静脉血浆中VIP浓度没有显著性变化（P＜0．05）。本实验证实，VIP是参与人类阴茎勃起反应的重要神经递质。
Intracavernosal vasoactive intestinal polypeptied (VIP) levels were measured in normal volunteers and men with predominantly organic or predominantly psychogenic impotence.The measurements were taken at intervals up to 30min following intracavernosal injections of aline、papaverine hydrochloride and papaverine hydrochloride and phentolamine.A penile erection occurred in all men receiving intracavernosaI vasoactive compounds. The median VIP concentrations altered significantly in cavernosal blood during the erection. Median peripheral venous VIP concentrations did not alter significantly after peripheral venous injection of papaverine plus phentolamine. These findings support the contention that VIP may be the principal neurotransmitters involved in penile erection.
