113例前列腺疾病临床病理观察

Ciinicopathological study of 113 cases prostate disease

目的 探讨免疫组化在前列腺疾病病理诊断中的作用。方法 采用免疫组化方法，观察PSA、34βE12、p63、p504S在不同前列腺疾病中的表达情况。结果 42例BPH、5例LGPIN、3例HGPIN、8例AAH、7例PAH均有341βE12、p63、PSA不同程度阳性表达；p504S在8例前列腺癌和3例HGPIN中具有较好阳性表达。结论 尽管PSA、34βE12、p63、p504S联合应用可以提高前列腺疾病的诊断正确率，但在经尿道切除前列腺和根治性前列腺标本中意义不如在穿刺活检中那样重要。

Objective To investigate the immunohistochemistry of prostate disease in pathological diagnosis. Methotis To observe the expression of PSA,34βE12, p63, p504S in different prostate disease. Results 42 cases of BPH, 5 cases of LGPIN, 3 cases of HGPIN, 8 cases of AAH, 7 cases of PAH have various positive expression in 34βE12, p63, PSA. p504S are of better sensitivity and specificity in 8 cases of prostate cancer and 3 patients with HGPIN. Conclusion The rate of correct diagnosis can increase with PSA, 34βE12, p63, p504S, but it is less significant in the transurethral resection of the prostate and radical prostatectomy specimens than in the the biopsy.