摘要
Rex-1(reduced expression 1)又称Zfp-42(zinc finger protein 42),是一种酸性锌指结构蛋白,在胚胎干细胞和部分成体干细胞中高表达,并随维甲酸(retinoid acid,RA)诱导干细胞分化而迅速下调。该分子的结构特点提示其具有转录调控的功能,对决定干细胞的状态和发育阶段发挥重要作用。
Rex-1 (reduced expression 1), also known as Zfp-42(zinc finger protein 42), encodes a protein containing four repeats of the zinc finger motif and an acidic domain. These structural features imply a possible regulatory function for Rex-1. Expression of Rex-1 is high in embryonic and several adult stem cells, and rapidly reduced after RA-induced differentiation. The unique expression profile of Rex-1 suggests that it may play an important role in deciding the status and fate of stem cells.
出处
《生命科学》
CSCD
北大核心
2009年第1期81-85,共5页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金项目(30700418)
关键词
Rex-1
干细腮
分化
转录调控
Rex-1
stem cells
differentiation
transcriptional regulation