角化棘皮瘤21例临床及病理分析(附1例电镜观察)

Clinicai and pathological analysis of 21 cases of keratoacanthoma (One SM examination).

报告２１例角化棘皮瘤。临床表现均为单发性，开始为一小的丘疹，迅速增大为半球状隆起于皮面的结节或肿块，中央呈火山口样凹陷，其内充满角质。组织病理变化：早期损害表皮凹陷如火山口样，充满角质物。底部表皮增生，有些病例含有不典型细胞、核丝分裂及角珠。充分发展的损害，火山口样凹陷继续扩大，两侧表皮如拱璧状。２０例的瘤底部较平坦，界限清楚，但另１例瘤的底部个别上皮细胞侵入横纹肌束之中。真皮内可见致密的嗜中性白细胞及嗜酸性白细胞浸润。超微结构显示增生的上皮细胞表面有许多不规则波浪状的微绒毛，桥粒数目增多，张力微丝减少。

cases of keratoacanthoma were reported.The clinical pictures showed that all were single lesion. At first,the lesion was a small papule,then enlarged to hemispheric nodule or tumor with crateriform depression in central.It was fulled with keratotic material.Histopathological examination showed,in the earlier lesion,the epidermis with crateriform depression, full with keratotic material and hyperplasia of basal cell layer,some of which showed mitosis and keratotic pearls.In the well developed lesion,the crateriform depression gradually enlarged,its wall was well demarkated.In 20 of 21 cases,the base of tumor were flattened,well demarkated,while in the other one,the base of tumor showed epidermal cells dipped into the straited muscle bundles.In the dermis,there was dense in filtration of neutrophils and eosinophils.SM examination of one case showed on the surface of epithelial cells there was irregular wave-shaped microvilli,increase of desmosomes,lots of which were intracytoplasam and there was deqcrease of tonofibrols.