小儿肝母细胞瘤术前化疗的组织学改变

Histological Changes in Hepatoblastoma by Neoadjuvant Chemotherapy with Cisplatin and Adramycin

目的观察肝母细胞瘤术前化疗后的组织学变化。方法采用软X线拍片、瘤组织浸泡银染方法，比较5例肝母细胞瘤化疗前后的组织学变化。结果化疗后瘤组织发生明显的坏死、纤维化，面积达80％以上。栓塞剂在瘤组织中的分布与瘤组织坏死纤维化的分布及程度无关。结论进展期肝母细胞瘤术前化疗有效。较短时间的肝动脉栓塞化疗可以达到与静脉化疗相近的组织学上的抗肿瘤效果。

[Pupose] To study the hisological changes in hepatoblastoma (HB)by neoadjuvant chemotherapy with cisplatin and adramycin regimen. [Methods] Tissue blocks of 5 cases with HB were processed by sorft tissue radiography and a modififed silver impregnation technigue to compared thehistological changes in prechemotherapy and poschemotherapy. Results There were obvious necrosis and fibrosis in the postchemotheraputic tissue,which accouted for more than 80 percent areas of the tissue. It seems no clear correlation between the lipiodol distribution and the extent,and distribution of necuosis or fibrosis. Conclusions Neoadjuvant chmotherapy with cisplatin and adranmycin by either introveneous or lipiodol-cisplatinchemoembolization has a histologically proved antitumor effect in advanced HB. The effect of a shorter period(2 cycles)exposure to lipiodol-cisplatinchemoembolization is similar to that of standard exposure(3 cycles)to cisplatin and adramycin regimen introveneously.