大肠类癌临床病理特征及其意义

Clinical and pathalogical characteristic of colorectal carcinoid and prognosis

目的分析大肠类癌的临床病理特征及诊治方法。方法回顾性分析第二军医大学长海医院肛肠外科自1993年1月至2007年11月收治的121例大肠类癌临床资料。结果121例大肠类癌病人男女比例为男:女=1.42:1,年龄平均(49.3±13.0)岁,其中位于直肠111例(91.7%),阑尾6例(5.0%),结肠4例(3.3%)。5年累计存活率83.5%,肿瘤直径和浸润深度相关(P<0.001),且二者分别与症状出现与否有关(P<0.05);神经特异性烯醇化酶(NSE)的表达与肿瘤直径有关(P<0.01)。结论直肠类癌发生率高,并有增加趋势。大肠类癌无特异性表现,病理诊断对治疗方案的选择及判断预后有重要作用,外科手术应施行个体化治疗。

Objective To study clinical and pathalogieal characteristic of eolorectal carcinoid and its treatment. Methods Clinical data of 121 patients with colorectal carcinoid were analyzed retrospectively. Results The Male/ female ratio was 1.42/1. The average age was （49.3± 13.0）years old. 111 cases of which was located in rectum, 6 cases in appendix, 4 cases in colon. 5-year cumulative survival rate of total patients was 83.5%.Patients with rectal carcinoid whose tumor 〈2cm had a significantly longer survival than those with tumor ≥2cm （P 〈0.001）.Patients whose lesions were in different intestinal wall had a different survival too（P〈0.001）.NSE expression and tumor diameter was related （P 〈 0.01）. Conclusion Incidence of colorectal is high, and it has been an upward trend. Colorectal carcinoid isnot specific performance. The pathological diagnosis has an important role in choosing treatment options and predicting prognosis. Surgery should be implemented in accordance with individual treatment.