采用合理用药国际指标干预和评估我院甲状腺切除围术期应用抗菌药物

Application of International Index of Rational Drug Use in the Intervention and Evaluation of the Rational Utilization of Antibiotics During Perioperative Period in Patients Undergoing Thyreoidectomy

目的:探讨采用合理用药国际指标干预和评估我院甲状腺切除围术期合理应用抗菌药物的可行性。方法:在我院普外科设立干预组和非干预组,参考合理用药国际指标对干预前(2007年3～8月)和干预后(2008年3～8月)同期出院的甲状腺手术患者进行对照研究。结果:干预后,干预组预防性应用抗菌药物平均持续时间由6.83d缩短至2.50d,平均住院时间由8.24d缩短至7.15d,平均住院药费由1895.99元下降至1375.26元,抗菌药物费用由852.11元下降至538.53元,抗菌药物费用占住院药费的比例有所下降;非干预组在同期各项指标变化不大。结论:采用合理用药国际指标干预和评估围术期合理应用抗菌药物具有有效性和可操作性。

OBJECTIVE： To explore the feasibility of using international index of rational drug use for the intervention and evaluation of rational use of antimicrobial agents during perioperative period in patients undergoing thyreoidectiomy. METHODS： The patients in the common surgical department were divided into intervention group and non-intervention group. An intervention control study was performed before intervention （from Mar. to Aug. in 2007） vs. after intervention （from Mar. to Aug. in 2008） on the synchronously discharged thyreoidectomy patients with the international index of rational drug use as references. RESULTS： After prophylactic use of antibiotics in the intervention group, the average antimicrobial application time was decreased from 6.83 days to 2.50 days, the average hospital stay of patients was decreased from 8.24 days to 7.15 days, the average hospitalization fee decreased from 1 895.99 yuan to 1 375.26 yuan, the cost of antibacterials decreased from 852.11 yuan to 538.53 yuan, and the proportion of the cost of antibacterials in the total hospitalization cost reduced slightly. However, all the indexes in the non- intervention group showed little change. CONCLUSION： It is effective and feasible to adopt the international index of rational drug use in the intervention and evaluation of rational use of antimicrobial agents during perioperative period.