促生素治疗溃疡性结肠炎的循证研究

Evidence-based Study on Probiotics for Ulcerative Colitis

目的:评价促生素在治疗溃疡性结肠炎(UC)方面的效果。方法:检索近年来发表在PubMed、Medline上关于促生素治疗UC的文献,按循证医学文献质量评价标准对其进行方法学与文献质量分析。结果与结论:大多数研究均表明,促生素在UC急性期缓解及维持药物诱导缓解方面均具有积极作用。微生态制剂作为一种新型的治疗方式应用于UC的临床治疗,尚需开展一些严格设计的、随机对照试验来解决一些治疗过程可能面临的问题。

OBJECTIVE： To evaluate the efficacy of Probiotics in the treatment of ulcerative colitis （UC） . METHODS： The recent pertinent literature about the use of Probiotics in the treatment of UC was retrieved from PubMed and Medline and the methodology and literature quality were evaluated in accordance with the evaluation criteria for the quality of literature of evidence- based medicine. RESULTS ＆ CONCLUSION： The majority of the studies showed that Probiotics are of positive value for the remission of the US at acute stage and maintaining of remission induction of drugs in the treatment of UC. Strictly designed and randomized controlled trials （RCTs） remain to be done to tackle the problems encountered by the micro-ecological preparations as a new therapy in the treatment of UC.