慢性阻塞性肺疾病住院患者药物相互作用调查

Analysis of Drug Interactions in the Inpatients with Chronic Obstructive Pulmonary Disease

目的:了解慢性阻塞性肺疾病住院患者药物治疗及不良相互作用的发生情况。方法:从清华大学第一附属医院2006年10月～2007年2月所有被诊断为慢性阻塞性肺疾病的住院病历中随机抽取54份,调查患者的基本情况及用药情况。结果:慢性阻塞性肺疾病住院患者超过20%的时间应用8种以上药物,70%的患者存在不良相互作用。结论:该院慢性阻塞性肺疾病住院患者用药种类过多,产生不良相互作用情况较多,应采取干预措施。

OBJECTIVE： To investigate the situation of drug use and occurrence of side effects of drug interactions in the inpatients with chronic obstructive pulmonary disease （COPD） . METHODS： 54 medical charts of the inpatients in the First Affiliated Hospital of Tsinghua University diagnosed as having COPD from Oct. 2006 to Feb. 2007 were randomly collected for analyses of patients＇ basic information drug utilization. RESULTS： The COPD patients received more than 8 kinds of drugs simultaneously in more then 20% of their hospital days. Side effects of drug interaction occurred in 70% of them. CONCLU- SION： The study shows that the drug use in the COPD inpatients is characterized by excessive drug kinds and high incidences of drug interactions, therefore, it is urgent to take further intervention measures on drug use in COPD inpatients.