3Laasila K, Leirisalo Repo M. Side effects of sulphaslszine in patients with rheumatic diseases of inflame matory bowel disease [ J ]. Scand JRheumatol, 1994,23 ( 6 ) : 338-340
4Clegg DO, Reda DJ , Weis man MH. Comparison of sulfasazine and placebo in the treat ment of ankylosing spondylitis, a Department of Veterans Affairs [ J ]. Cooperative study. Arthritis Rheum, 1996,39 (12) :2 004-2 012
5Greene S Watanabe K, Braatz Trulsn J,et al. Inhibition of dihydroorotate dehydrogenase by the immunosupressive agentlef lunomide [ J ]. Biochem Pharmacol, 1995,50 ( 6 ) : 861
1[1] Barlett RR,Anagnostopulos H,Zielinski T,et al.Effects of leflun o mide on immune responses and models of inflammation.Springer Semin Immunopathal, 1993,14∶381-394.
2[2] Weaver A, Caldwell J, Olsen N et al. Treatment of active rheumat oid arthritis with leflunomide compared to placebo or methotrexate. ACR Concurre nt Session，1998, Abstract∶593.
3[3] Finnegan A,Siemasko K F,Williams J W，et al.Leflunomide inhibits immunog lobin prodution by two separate mechanism.ACR Poster Session,1997,40.
4[4] Barlett R.R，et al. Leflunomide, an imunorestoring drug for the therapy autoimmune disorders, especially rheumatoid. Current Opinion in Rheumatoid， 199 7，9∶410.
5[5] Prakash M, Jarvis B. Leflunomide, a review of its use in active rheumat oid arthritis.1999,58(6)∶1137-1164.
6[6] Weinblatt ME, Kremer JM, Coblyn JS，et al. Leflunomide plus methotrexate in refractory rheumatoid arthritis: A pilot study. ACR Poster Session，1997,Abs tract∶974.
6Kaltwasser JP.Leflunomide in psoriatic arthritis. Autoimmunity Reviews . 2007
7van,Denderen,J.C.,van der,Paardt,M.,Nurmohamed,M.T.Double blind, randomised, placebo controlled study of leflunomide in the treatment of active ankylosing spondylitis. Annals of the Rheumatic Diseases . 2005
8Van der Linden S,Valkenburg HA,Cats A.Evaluation of diagnostic criteria for ankylosing spondylitis: a proposal for modification of the New York criteria. Arthritis and Rheumatism . 1984
9HAIBEL H,RUDWALEIT M,BRAUN J,et al.Sixmonths open label trial of leflunom ide inactive ankylosingspondylitis. AnnRheumDis . 2005
