Tau蛋白的研究进展

Research Development of Tau Protein

Tau是一种微管相关蛋白,主要在神经细胞中表达,作用是促进微管的聚集及微管的稳定。在一些神经退行性的疾病中,如人类的阿尔氏海默氏病(Alzheimer’sdisease,AD)、皮克氏病(Pick’sdisease,PD)、牛的海绵状脑病(Bovinespongiformencephalopathy,BSE)等,Tau的代谢机制均发生了变化。这些Tau蛋白的改变包括突变、转录后修饰(如磷酸化)、异常Tau聚集以及自身不同异构体的表达,这些都能够引起病理学效应,从而导致神经紊乱症状的出现,这类疾病亦被称为Tau蛋白病(Tau病)。本文介绍Tau蛋白及其功能,并综述近期的研究进展。

Tau is a microtubule-associated protein predominantly expressed in nerve cells that promote microtubule assembly and microtubule stabilization In several neurodegenerative diseases, as for example Alzheimer＇s disease,Pick＇s disease in human. Bovine spongiform encephalopathy and otherwise, tau metabolism is altered Thus, alterations in the amount of the tau protein, mutations, post-transcriptional modifications like phosphorylation. aberrant tau aggregation or a different expression of some of its isoforms could provoke pathological effects resulting in the appearance of neuronal disorders known as tauopathies. Thus, here we intend to introduce this protein and its function, also to understand recent developments.